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Penicillin

  • History of the miraculous drug penicillin
  • What is Penicillin?
  • Penicillin is a substance with bactericidal properties, produced by the mold insect type ‘Penicillum notatum‘. The substances with bactericidal properties are called antibiotics. Penicillin is of particular importance in terms of being the first antibiotic to be discovered.

 

  • How was Penicillin Found?
  • Penicillin was discovered incidentally in 1928 by the Scottish bacteriologist Sir Alexander Fleming. Fleming was producing bacteria in the culture containers in the laboratory of the hospital where he worked in London. When he returned from his lab for a month, he found that the bacterium could not reproduce in the culture cabinet where he produced a harmful bacterial strain called ‘Staphylococcus’. He produced this mold mushroom, which he separated from the culture site, on the medium he prepared with meat and water. These mold fungi of the Penicillium species, which can be produced in cheese, stale bread and moist walls, are derived from the word ‘penicillin‘ in Latin meaning ‘brush‘ because they resemble the tiny paint brushes when viewed microscopically.

 

    Penicillum notatum

    Penicillum notatum

  • Flaming was not interested at the time when his patients were dying because of bacterial infection and their lives were rescued by treatment with Penicillin. He could not find any financial means to further his work, so he stopped working on Penicillin. Sir Howard Florey and Ernst Boris Chain; They supported the Flaming by bringing the penicillin into drug form. With the use of penicillin, millions of people have been saved from dying of inflammatory disease caused by bacteria. 3 scientists won the Nobel Prize in 1945.

 

  • Use of penicillin in ancient times
  • Thousands of years ago, it was observed that the kufes healed the wounds. Moldy soy flour in China; Beer made with stale bread in Sumerians; In Mesopotamia and Ukraine, the soil was used for antibiotics for wounding due to its mold.

 

  • Previous situation from Fleming
  • Joseph Lister said that in 1871, bacteria did not grow in mold-faded urine; Louis Pasteur stopped the anthrax activity in 1877; Ernest Duchesne observed in 1897 that mold fungus inhibited the growth of parcels. However, those who made these observations could not scratch the penisilin.

 

  • Today, penicillin has natural and synthetically different forms. One thing to note is that penicillin-like antibiotics can cause an allergic reaction in some people. In some of the cases, the most serious form of allergic reaction, anaphylaxis, can develop. For this reason, people who will be administered penicillin for the first time should firstly determine whether they are sensitive to penicillin by skin test.
Penicillin
Author: wik Date: 1:56 pm
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